Cystine glutamate
WebMar 29, 2024 · The small-molecule compound erastin induces ferroptosis via inhibiting the cystine-glutamate antiporter system x c –, which consists of two subunits, namely the … WebMay 20, 2014 · Exchange of extracellular cystine for intracellular glutamate by the antiporter system x c − is implicated in numerous pathologies. Pharmacological agents that inhibit system x c − activity with high potency have long been sought, but have remained elusive. In this study, we report that the small molecule erastin is a potent, selective …
Cystine glutamate
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WebOct 1, 2024 · The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers. Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis, a form of … WebAug 1, 2024 · In many cultured cells, xCT is induced by various stimuli such as electrophilic agents [15], amino acid deprivation [16], bacterial lipopolysaccharide [17], and contributes to the maintenance of intracellular glutathione level. xCT is the main component of the system x c − and mediates the transport of cystine and cystathionine into cells in exchange with …
WebFeb 2, 2024 · In the present study, we found that autophagy has a selective role in sustaining cysteine (Cys) pools in PDAC. One of the major mechanisms of Cys homeostasis is through the import of cystine (the oxidized dimer of cysteine) through system x c −, a cystine/glutamate antiporter composed of SLC7A11 (xCT) and SLC3A2 . WebNov 22, 2002 · In mammalian cultured cells, the cystine/glutamate exchange transport mediated by system x c − is important to maintain intracellular GSH levels. System x c − consists of two protein components, xCT and the heavy chain of 4F2 antigen. The activity of system x c − is induced by various stimuli, including electrophilic agents like diethyl maleate.
WebApr 15, 2024 · The other mechanism of L-Glu toxicity is via non-receptor-mediated oxidative stress, which can involve the cystine/glutamate antiporter system (X c −) [22,32]. An overabundance of extracellular L-Glu blocks the cystine/glutamate antiporter system resulting in cysteine depletion, and this is a primary component for the synthesis of the … WebSystem x(c)(-) is an amino acid antiporter that typically mediates the exchange of extracellular l-cystine and intracellular L-glutamate across the cellular plasma …
WebApr 26, 2024 · The poorer prognosis of AML patients expressing higher levels of SLC7A11 which encodes the cystine/glutamate antiporter xCT was confirmed in a third cohort of …
WebMar 29, 2024 · Ballatori N, Jacob R, Boyer JL. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. J Biol Chem. 1986 Jun 15;261(17):7860-5. tea-opium connectionWebFeb 15, 1986 · Cystine and glutamate at one side of the membrane stimulate the passage of these amino acids present at the other side of the membrane. When the concentration … tea operation connectivityWebApr 14, 2024 · For example, glutamate plays an important role in mediating neuronal damage during cerebral ischemia. Glutamine, the main precursor of glutamate, was detected at significantly higher level in the plasma of patients with ischemic stroke. Phenylalanine is a derivative from glutamate and its metabolite is tyrosine. tea oolong teaWebDec 8, 2024 · System xc- is a cystine transporter that is expressed in the plasma membrane and imports cystine in exchange for intracellular glutamate. Here, the authors present the cryo-EM structure of human ... tea open education resourcesWebThe effect of different concentrations of cysteine (0.125, 0.25, 0.5 and 1 mM) on the net efflux of endogenous amino acids was studied by the incubation of rat hippocampal slices. Addition of cysteine (1 mM) in bicarbonate containing low K + medium (5 min) selectively increased the basal net efflux of glutamate and aspartate by 370% and 396%, respectively. tea oolongWebMay 1, 2024 · Helicobacter pylori infection is a major cause of gastrointestinal diseases. However, the pathogenesis of gastric mucosal injury by H. pylori remains unclear. Exogenous glutamate supplementation protects against gastric mucosal injury caused by H. pylori.Previously, we showed that aspirin-induced gastric injury is associated with … teaor 2023WebMay 20, 2014 · Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc (-) is implicated in numerous pathologies. Pharmacological agents … teaor 1071