WebJan 28, 2024 · We observed an increase in NOXA-encoding mRNA in response to AUR (Fig. 6A) and concentration-dependent accumulation of NOXA protein in MLLr BCP-ALL cell lines (Fig. 6B), PDXs (n = 8, Fig. 6C), as ... WebNov 28, 2003 · Genotoxic stresses stabilize the p53 tumor suppressor protein which, in turn, transactivates target genes to cause apoptosis. Although Noxa, a “BH3-only” member of the Bcl-2 family, was shown to be a target of p53-mediated transactivation and to function as a mediator of p53-dependent apoptosis through mitochondrial dysfunction, the molecular …

proteasome inhibitor bortezomib induces apoptosis in mantle-cell ...

WebMay 15, 2008 · Moreover, Mcl-1, one of the 2 antiapoptotic protein that Noxa binds, 29,30,38 was down-regulated in this cell line, resulting in a net increase in Noxa relative to its target. Puma was also up-regulated in all the cell lines, but consistent with the array data, primarily in MM.1s, while Bim expression was relatively unchanged during ATO-induced apoptosis ( … WebMar 8, 2024 · Noxa, encoded by PMAIP1 gene, is a pro-apoptotic protein in the B-cell lymphoma 2 family proteins, which belongs to a subclass of BH3-only proteins. Noxa plays a crucial role in the interactions ... contact number tax act

Knockout of Noxa with CRISPR/Cas9 Increases Host Resistance …

Lung adenocarcinoma is recalcitrant cancer with overall survival of less than 5 years (Denisenko et al., 2024). Intolerable side effects and multidrug resistance are still the main causes … See more In the present study, we found that AD exhibits a broad-spectrum inhibition of proliferation in lung cancer cells, and firstly demonstrated that AD activated the ATF4/Noxa axis to induce apoptosis of human lung … See more The original contributions presented in the study are included in the article/Supplementary Material, and further inquiries can be directed to the corresponding author. See more WebNov 23, 2012 · A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia. November 2012; Cancer Gene Therapy 20(1) DOI: 10.1038/cgt.2012.84. WebApr 4, 2024 · NOXA protein, known as a sensitizer for inducing apoptosis, is a pro-apoptotic BCL2 family protein. 44 Several studies have reported the significance of NOXA in … ee-office-zju-edu-cn